Study Design 


1. Compare results to the VN1203 wild-type virus

2. RNA and Protein samples for arrays analysis and proteomics.

3. Determine viral infection phenotypes (% of cell infected, % weight loss and survival).

General Design:

Use 20 week-old C57BL/6 mice

Use VN1203 PB2 627E

Dosage = 10^4 PFU

Time points of 1, 2, 4 and 7 days.

5 mice/time point for infections and 3 mice/time point for time matched mocks

Metadata is available in the sub-folders on the right.

Microarray data and global proteomics data is also available.