Study Design 

Purpose:

  • Compare results to the VN1203 wild-type virus
  • RNA and Protein samples for arrays analysis and proteomics.
  • Determine viral infection phenotypes (% of cell infected, % weight loss and survival).

General Design:

  • Use 20 week-old C57BL/6 mice
  • Use VN1203 PB1-F2 Del
  • Three doses = 10^2, 10^3, and 10^4 PFU
  • Time points of 1, 2, 4, and 7 days
  • 5 mice/time point for infections
  • 3 mice/time point for time matched mocks

Metadata is available in the sub-folders on the right.

Microarray data and global proteomics data is also available.

NOTE:  Only samples from the 10^3 and 10^4 PFU doses were processed for microarrays and proteomics.


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