Study Design 

1. Compare results to the VN1203 wild-type virus
2.  RNA and Protein samples for arrays analysis and proteomics.
3. Determine viral infection phenotypes (% of cell infected, % weight loss and survival).

General Design:
Use 20 week-old C57black6 mice
Use VN1203 NS1-trunc
Three doses = 10^2, 10^3, and 10^4 PFU 
Time points of 1, 2, 4 and 7 days.
5 mice/time point for infections
3 mice/time point for time matched mocks

Metadata is available in the sub-folders on the right.

Microarray data and global proteomics data is also available.

NOTE: We did transcriptomic and proteomic analysis on 10^3 and 10^4 PFU doses.