Study Design 


To investigate differences between wild type MA15 infection, icSARS and the Bat SRBD mutant viruses.

Overview of Experiment:

  • 20 week old C57BL/6 mice infected with:

o    MA15 at 10^4 or 10^5 PFU (4 animal/time point)

o    icSARS at 10^5 PFU (5 animals/ time point)

o    Bat SRBD at 10^4 PFU (5 aminals/time point)

o    mock infected (4-5 animals/time point)

  • Time points:1, 2, 4, and 7 days post infection
  • Assays: virus load, lung pathology, transcriptional and proteomics analysis.
  • Mice will be weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss will be euthanized.

Metadata is available in the sub-folders on the right.

Microarray data is also available.