Study Design 

Purpose:

To test our hypotheses that major components of the extracellular matrix remodelling pathways are important for SARS-CoV pathogenesis in mice.

Overview of Experiment: 

  • 20 week old C57BL/6, TIMP1 or Serpine1 knockout mice:

o    MA15 at 10^4 PFU

o    Mock infected.

  • Mice will be euthanized on days 4 and 7 post infection
  • Assays: Virus load, lung pathology
  • Mice will be weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss will be euthanized.

Metadata is available in the sub-folders on the right.

Microarray data is also available.


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