To test our hypotheses that major components of the extracellular matrix remodelling pathways are important for SARS-CoV pathogenesis in mice.
Overview of Experiment:
- 20 week old C57BL/6, TIMP1 or Serpine1 knockout mice:
o MA15 at 10^4 PFU
o Mock infected.
- Mice will be euthanized on days 4 and 7 post infection
- Assays: Virus load, lung pathology
- Mice will be weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss will be euthanized.
Metadata is available in the sub-folders on the right.
Microarray data is also available.