Experiment Overview 

Purpose: To investigate differences between wild type MA15 infection of C57BL/6 mice and KEPI knockout mice.

Experimenal Design: 

  • Groups of 10 week old C57BL/6 mice or KEPI knockout mice will be infected MA15 at a dose of 10^5 PFU or mock infected. 
  • Mice will be euthanized on days 4 and/or 7 post infection to isolate samples for measurement of virus load, lung pathology,  transcriptional and proteomics analysis.  Mock infected animals will also be harvested at each time point.
  • Mice will be weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss will be euthanized.

 

Microarray data is also available.


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