Purpose: To investigate differences between wild type MA15 infection of C57BL/6 mice and KEPI knockout mice.
- Groups of 10 week old C57BL/6 mice or KEPI knockout mice will be infected MA15 at a dose of 10^5 PFU or mock infected.
- Mice will be euthanized on days 4 and/or 7 post infection to isolate samples for measurement of virus load, lung pathology, transcriptional and proteomics analysis. Mock infected animals will also be harvested at each time point.
- Mice will be weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss will be euthanized.
Microarray data is also available.