Analytical Performance of thrombospondin-1 and Cathepsin D Immunoassays


systemsvirology

Analytical Efficiency of thrombospondin-1 and Cathepsin D Immunoassays A part of a Novel CE-IVD Marked Check as an Help within the Prognosis of Prostate Most cancers

The Prostate Particular Antigen (PSA) take a look at suffers from low specificity for the analysis of Prostate Most cancers (PCa). We initially found two cancer-related proteins thrombospondin-1 (THBS1) and cathepsin D (CTSD) utilizing a mass-spectrometry-based proteomics method.

The 2 serum proteins had been proven to enhance the analysis of high-grade PCa. Thus, we developed quantitative ELISAs for the dedication of their focus in human serum. Right here we report their analytical efficiency by way of restrict of detection, specificity, precision, linearity and interferences, which had been decided based mostly on CLSI tips. Additional, we investigated the affect of pre-analytical elements on focus measurements.

For this, blood from 4-6 donors was collected in numerous tubes and saved at room temperature for various occasions previous to centrifugation at completely different centrifugal forces and temperatures. Stability of THBS1 and CTSD underneath completely different storage temperatures was additionally evaluated.

Our outcomes present that the assays are particular, linear and delicate sufficient to permit measurement of scientific samples. Precision by way of repeatability and whole within-laboratory coefficient of variation (CV) are 5.5% and eight.1% for THBS1 and 4.3% and seven.2% for CTSD, respectively. Relative laboratory-to-laboratory variations had been -6.3% for THBS1 and -3% for CTSD.

Each THBS1 and CTSD had been steady in serum samples, with 80-120% recoveries of concentrations throughout donors, pattern preparation and storage. In conclusion, the ELISAs as a part of the novel business in vitro diagnostic take a look at Proclarix are appropriate for the use in scientific observe. THBS1 and CTSD may be precisely measured for his or her meant use unbiased of the lot and laboratory when situations according to routine observe for PSA sampling and storage are used.

Optimization of a rat lumbar IVD degeneration mannequin for low again ache

Introduction: Intervertebral disc (IVD) degeneration is commonly related to low again ache and radiating leg ache. The aim of this examine is to develop a reproducible and standardized preclinical mannequin of painful lumbar IVD degeneration by analysis of structural and behavioral adjustments in response to IVD harm with rising needle sizes. This mannequin can be utilized to develop new therapies for IVD degeneration.

Strategies: Forty-five feminine Sprague Dawley rats underwent anterior lumbar disc needle puncture at ranges L4-5 and L5-6 underneath fluoroscopic steerage. Animals had been randomly assigned to 4 completely different experimental teams: needle sizes of 18 Gauge (G), 21G, 23G, and sham management. To observe the development of IVD degeneration and ache, the next strategies had been employed: μMRI, qRT-PCR, histology, and biobehavioral evaluation.

Outcomes: T1- and T2-weighted μMRI evaluation confirmed a correlation between the diploma of IVD degeneration and needle diameter, with essentially the most extreme degeneration within the 18G group. mRNA expression of markers for IVD degeneration markers had been dysregulated within the 18G and 21G teams, whereas pro-nociceptive markers had been elevated within the 18G group solely. Hematoxylin and Eosin (H&E) and Alcian Blue/Picrosirius Crimson staining confirmed essentially the most pronounced IVD degeneration within the 18G group. Randall-Selitto and von Frey checks confirmed elevated hindpaw sensitivity within the 18G group.

Conclusion: Our findings reveal that anterior disc harm with an 18G needle creates extreme IVD degeneration and mechanical hypersensitivity, whereas the 21G needle leads to reasonable degeneration with no elevated ache sensitivity. Subsequently, needle sizes ought to be chosen relying on the specified phenotype for the pre-clinical mannequin.

systemsvirology
systemsvirology

Gentamicin-BSA

80-IG10 25 mg
EUR 457.2
Description: Conjugated Gentamicin-BSA hapten

Gentamicin Solution, Gentamicin Solution, 50 mg/mL

CCM1123-010 10 mL
EUR 76.86

Gentamicin(GM)

AT022 1mg
EUR 1134

Gentamicin(GM)

AG022 1 mg
EUR 627.6

Gentamicin [KLH]

DAG4484 1mg
EUR 1248

Gentamicin [HRP]

DAGA-032H 1mg
EUR 1248

Gentamicin-HRP

65-IG10 1 mg
EUR 716.4
Description: Conjugated Gentamicin-HRP hapten

Gentamicin-OVA

80-1455 1 mg
EUR 781.2
Description: OVA conjugated Gentamicin Hapten

Gentamicin-OVA

80-1456 1 mg
EUR 781.2
Description: OVA conjugated Gentamicin Hapten

Gentamicin sulfate

B1270-1G each
EUR 170.4

Gentamicin sulfate

B1270-25G each
EUR 1136.4

Gentamicin sulfate

B1270-5G each
EUR 405.6

Gentamicin sulfate

GA7939-10G 10 g
EUR 122.4

Gentamicin sulfate

GA7939-1G 1 g
EUR 55.2

Gentamicin sulfate

GA7939-25G 25 g
EUR 189.6

Gentamicin sulfate

GA7939-5G 5 g
EUR 93.6

Gentamicin (sulfate)

HY-A0276 500mg
EUR 142.8

Gentamicin antibody

10-1541 100 ug
EUR 470.4
Description: Mouse monoclonal Gentamicin antibody

Gentamicin antibody

20-GG15 250 ul
EUR 220.8
Description: Goat polyclonal Gentamicin antibody

Gentamicin antibody

20-GR15 250 ul
EUR 249.6
Description: Rabbit polyclonal Gentamicin antibody

Gentamicin antibody

10-G02A 500 ug
EUR 591.6
Description: Mouse monoclonal Gentamicin antibody

Gentamicin antibody

20C-CR1031S 1 ml
EUR 262.8
Description: Sheep polyclonal Gentamicin antiserum

Gentamicin Antibody

abx021011-200ug 200 ug
EUR 393.6

Gentamicin Antibody

abx021012-1mg 1 mg
EUR 1144.8

Gentamicin Antibody

abx021013-1mg 1 mg
EUR 577.2

Gentamicin Antibody

20-abx210193
  • EUR 526.80
  • EUR 393.60
  • 100 ug
  • 50 ug

Gentamicin, 50mg/ml

CA003-001 10ml
EUR 109.2

Gentamicin ELISA kit

55R-2233 1 kit
EUR 837.6
Description: Gentamicin ELISA kit for use in research laboratory

Gentamicin ELISA Kit

DEIA047 96T
EUR 1238.4
Description: This kit can be used in quantitative and qualitative analysis of gentamicin residue in vaccine and cell culture.

Gentamicin ELISA Kit

K4206-100 each
EUR 1188

Gentamicin Sulfate EP

G007-25G 25 g
EUR 478.8

Gentamicin Sulfate EP

G007-5G 5 g
EUR 219.6

Gentamicin Sulfate USP

G006-25G 25 g
EUR 470.4

Gentamicin Sulfate USP

G006-5G 5 g
EUR 199.2

Sd Gentamicin Gm-10

231299 PK10
EUR 63.45

Gentamicin sulfate salt

20-abx082235
  • EUR 226.80
  • EUR 343.20
  • 100 mg
  • 1 g

Gentamicin (GTM) Antibody

20-abx175177
  • EUR 393.60
  • EUR 994.80
  • EUR 526.80
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

0.1g Gentamicin Sulfate Powder

61-098-RA EACH
EUR 58.37

1g Gentamicin Sulfate Powder

61-098-RF EACH
EUR 76.38

Gentamicin monoclonal antibody

10R-11497 1 mg
EUR 1332
Description: Mouse anti- Gentamicin monoclonal antibody

Gentamicin ELISA Kit (OKAO00127)

OKAO00127 96 Wells
EUR 638.4
Description: Description of target: Gentamicin is a complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.;Species reactivity: General;Application: ;Assay info: Assay Methodology: Competitive Inhibition ELISA;Sensitivity: _x000D__x000D__x000D__x000D_
ComponentAmount
Tissue6 ppb
Liver10 ppb
Milk15 ppb
Serum6 ppb

Gentamicin C1 pentaacetate salt

GA1270-10MG 10 mg
EUR 783.6

Gentamicin C1 pentaacetate salt

GA1270-1MG 1 mg
EUR 204

Gentamicin C2 pentaacetate salt

GA2476-5MG 5 mg
EUR 418.8

Gentamicin C1a pentaacetate salt

GA4559-10MG 10 mg
EUR 514.8

Gentamicin C1a pentaacetate salt

GA4559-25MG 25 mg
EUR 964.8

Gentamicin (serum/urine) ELISA Kit

K4315-100 each
EUR 907.2

Gentamicin C1 Sulfate EvoPure®

G031-10MG 10 mg
EUR 804

Gentamicin C2 sulfate EvoPure®

G033-10MG 10 mg
EUR 804

Gentamicin A sulfate EvoPure®

G035-10MG 10 mg
EUR 456

Gentamicin X2 sulfate EvoPure®

G036-2.5MG 2.5 mg
EUR 36

Gentamicin X2 sulfate EvoPure®

G036-PleaseContactusforPricing Please Contact us for Pricing
EUR 36

10mL Gentamicin Sulfate Liquid 5

30-005-CR PK10
EUR 578.4

Gentamicin C1a sulfate EvoPure®

G032-10MG 10 mg
EUR 804

Gentamicin C2a sulfate EvoPure®

G034-10MG 10 mg
EUR 804

Gentamicin C2b sulfate EvoPure®

G062-10MG 10 mg
EUR 615.6

GTTR [Texas Red gentamicin conjugate]

24300 100 ug
EUR 203

GTTR [Texas Red gentamicin conjugate]

24301 1 mg
EUR 989

Sheep Anti Gentamicin Polyclonal Antibody

DPBT-68266SG 0.5 ml
EUR 920.4

Mouse Anti Gentamicin Monoclonal Antibody

DMABT-54913MG 1 mg
EUR 920.4

Mouse Anti Gentamicin Monoclonal Antibody

DMABT-54914MG 1 mg
EUR 920.4

Gentamicin Sulfate Solution (50 mg/mL in Water)

G046-20ML 20 mL
EUR 132

SP-TL Supplement with BSA (Fract V), sodium pyruvate, and gentamicin to make SP-TALP (Tyrode's Albumin Lactate Pyruvate).

IVL03-100ML 100 ml
EUR 86.4
Description: Supplement with BSA (Fract V), sodium pyruvate, and gentamicin to make SP-TALP (Tyrode's Albumin Lactate Pyruvate).

SP-TL Supplement with BSA (Fract V), sodium pyruvate, and gentamicin to make SP-TALP (Tyrode's Albumin Lactate Pyruvate).

IVL03-6X100ML 6 x 100 ml
EUR 126
Description: Supplement with BSA (Fract V), sodium pyruvate, and gentamicin to make SP-TALP (Tyrode's Albumin Lactate Pyruvate).

HEPES-TL Supplement with BSA (Fract V), sodium pyruvate, and gentamicin to make HEPES-TALP (Tyrode's Albumin Lactate Pyruvate).

IVL01-500ML 500 ml
EUR 104.4
Description: Supplement with BSA (Fract V), sodium pyruvate, and gentamicin to make HEPES-TALP (Tyrode's Albumin Lactate Pyruvate).

HEPES-TL Supplement with BSA (Fract V), sodium pyruvate, and gentamicin to make HEPES-TALP (Tyrode's Albumin Lactate Pyruvate).

IVL01-6X500ML 6 x 500 ml
EUR 226.8
Description: Supplement with BSA (Fract V), sodium pyruvate, and gentamicin to make HEPES-TALP (Tyrode's Albumin Lactate Pyruvate).

IVF-TL Supplement with BSA (EFAF), sodium pyruvate, gentamicin, and heparin to make IVF-TALP (Tyrode's Albumin Lactate Pyruvate).

IVL02-100ML 100 ml
EUR 90
Description: Supplement with BSA (EFAF), sodium pyruvate, gentamicin, and heparin to make IVF-TALP (Tyrode's Albumin Lactate Pyruvate).

IVF-TL Supplement with BSA (EFAF), sodium pyruvate, gentamicin, and heparin to make IVF-TALP (Tyrode's Albumin Lactate Pyruvate).

IVL02-6X100ML 6 x 100 ml
EUR 154.8
Description: Supplement with BSA (EFAF), sodium pyruvate, gentamicin, and heparin to make IVF-TALP (Tyrode's Albumin Lactate Pyruvate).

TruStrip RDT Gentamicin rapid test strips, results is 2-10 mins, 50 strips/pk

DE-100200-RDT 1 pk Ask for price

Rat  Gentamicin (GTM) kit ELISA kit

E02G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat  Gentamicin (GTM) kit ELISA kit

E02G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat  Gentamicin (GTM) kit ELISA kit

E02G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig  Gentamicin (GTM) kit ELISA kit

E07G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig  Gentamicin (GTM) kit ELISA kit

E07G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig  Gentamicin (GTM) kit ELISA kit

E07G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog  Gentamicin (GTM) kit ELISA kit

E08G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog  Gentamicin (GTM) kit ELISA kit

E08G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog  Gentamicin (GTM) kit ELISA kit

E08G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat  Gentamicin (GTM) kit ELISA kit

E06G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat  Gentamicin (GTM) kit ELISA kit

E06G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat  Gentamicin (GTM) kit ELISA kit

E06G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human  Gentamicin (GTM) kit ELISA kit

E01G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human  Gentamicin (GTM) kit ELISA kit

E01G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human  Gentamicin (GTM) kit ELISA kit

E01G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse  Gentamicin (GTM) kit ELISA kit

E03G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse  Gentamicin (GTM) kit ELISA kit

E03G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse  Gentamicin (GTM) kit ELISA kit

E03G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey  Gentamicin (GTM) kit ELISA kit

E09G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey  Gentamicin (GTM) kit ELISA kit

E09G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey  Gentamicin (GTM) kit ELISA kit

E09G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit  Gentamicin (GTM) kit ELISA kit

E04G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit  Gentamicin (GTM) kit ELISA kit

E04G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit  Gentamicin (GTM) kit ELISA kit

E04G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig  Gentamicin (GTM) kit ELISA kit

E05G0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig  Gentamicin (GTM) kit ELISA kit

E05G0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig  Gentamicin (GTM) kit ELISA kit

E05G0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig  Gentamicin (GTM) kit in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Gentamycin [BSA]

DAG2993 1mg
EUR 858

Gentamycin [HRP]

DAG1198 10mg
EUR 1201.2

Gentamycin-HRP

80-1175 500 ul
EUR 970.8
Description: Gentamycin Conjugate for use in immunoassays

Gentamycin Sulfate

A2514-1000 1 g
EUR 166.8
Description: Gentamicin is an aminoglycoside antibiotic, always used the sulfate form, composed of a mixture of related gentamicin components and fractions ,which is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms.

Gentamycin Sulfate

A2514-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Gentamicin is an aminoglycoside antibiotic, always used the sulfate form, composed of a mixture of related gentamicin components and fractions ,which is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms.

Gentamycin antibody

20-1112 100 ul
EUR 1054.8
Description: Sheep polyclonal Trimethoprim antibody

Gentamycin Sulfate, 100g

R1405-100g each
EUR 649.2

Gentamycin Sulfate, 25g

R1405-25g each
EUR 228

Gentamycin/Amphotericin B Solution(100X)

CA700-050 500ml
EUR 208.8

BSA

31C-CH0114 50 mg
EUR 159.6
Description: Bovine Serum Albumin for use in the research laboratory

Testosterone 3 BSA Protein (BSA)

abx060856-1mg 1 mg
EUR 693.6

BSA Control for Age-BSA

2221-BSA each
EUR 210

BSA Control for AGE-BSA

35R-AA007 10 mg
EUR 268.8
Description: BSA Control for AGE protein (BSA modified), Cat No. 30R-AA007

THC (BSA)

abx080017-1mg 1 mg
EUR 510

SAH (BSA)

abx083009-50ug 50 ug
EUR 460.8

PCP [BSA]

DAG3015 1 mg
EUR 858

THC [BSA]

DAG406 1mg
EUR 858

Pb2+ [BSA]

DAGA-005B 1mg
EUR 1326

Cd2+ [BSA]

DAGA-006B 1mg
EUR 1076.4

Hg2+ [BSA]

DAGA-007B 1mg
EUR 1076.4

Cu2+ [BSA]

DAGA-008B 1mg
EUR 936

MDMA (BSA)

abx080012-1mg 1 mg
EUR 444

EDDP (BSA)

abx080038-1mg 1 mg
EUR 844.8

gABA (BSA)

20-abx165727
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

DHEA [BSA]

DAGPY6646 500ug
EUR 1014

BSA-SAH

ACT00301-50 50µg (20µg)
EUR 289.2
Description: BSA was conjugated to S-Adenosylhomocysteine. Coating for 10 96-well micro-titer plates.

BSA-HCY

ACT00501-100 100µg
EUR 487.2
Description: Bovine serum albumin (BSA) was conjugated to homocysteine (HCY).

Opium (BSA)

abx080050-1mg 1 mg
EUR 543.6

BSA-SAH

E62K00201 100ug
EUR 411.6

Sudan [BSA]

DAGA-075B 1mg
EUR 1014

Biotin [BSA]

DAG3197 1mg
EUR 577.2

Cocaine (BSA)

abx080052-1mg 1 mg
EUR 543.6

Carmine (BSA)

20-abx165660
  • EUR 693.60
  • EUR 309.60
  • EUR 2013.60
  • EUR 811.20
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Estriol (BSA)

20-abx165717
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glycine (BSA)

20-abx165740
  • EUR 727.20
  • EUR 309.60
  • EUR 2180.40
  • EUR 861.60
  • EUR 526.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Heparin (BSA)

20-abx165746
  • EUR 661.20
  • EUR 292.80
  • EUR 1914.00
  • EUR 777.60
  • EUR 493.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Digoxin [BSA]

DAG3043 0.5ml
EUR 858

Glycine [BSA]

DAG3313 250ug
EUR 858

Glyoxal [BSA]

DAG3314 250ug
EUR 936

Tylosin [BSA]

DAGA-047B 1mg
EUR 1014

Patulin [BSA]

DAGA-368B 1mg
EUR 1076.4

BSA Antigen

IM112 1 ml
EUR 342
Description: BSA Antigen by Cygnus Technologies is available in Europe via Gentaur.

BSA Antibody

5998-100 each
EUR 424.8

BSA Antibody

5998-30T each
EUR 175.2

BSA antibody

70C-CR1016GAP 1 mg
EUR 516
Description: Affinity purified Goat polyclonal BSA antibody

BSA antibody

70R-12462 100 ug
EUR 552
Description: Rabbit polyclonal BSA antibody

BSA antibody

70-BC67 1 mg
EUR 229.2
Description: Affinity purified Chicken polyclonal BSA antibody

BSA Antibody

48061-100ul 100ul
EUR 399.6

BSA Antibody

48061-50ul 50ul
EUR 286.8

BSA antibody

10-1911 200 ul
EUR 651.6
Description: Mouse monoclonal BSA antibody

BSA antibody

10R-A139B 500 µg
EUR 925.2
Description: Mouse monoclonal BSA antibody

BSA antibody

10R-1795 100 ul
EUR 522
Description: Mouse monoclonal BSA antibody

BSA antibody

10R-10573 100 ul
EUR 418.8
Description: Mouse monoclonal BSA antibody

BSA antibody

70R-AS001 500 ug
EUR 236.4
Description: Affinity purified Sheep polyclonal BSA antibody

BSA Antibody

20-abx322792
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

BSA antibody

20R-AR042 20 mg
EUR 392.4
Description: Rabbit polyclonal BSA antibody

BSA antibody

20R-1871 100 ug
EUR 807.6
Description: Rabbit polyclonal BSA antibody

BSA Antibody

35643-100ul 100ul
EUR 302.4

Ketamine (BSA)

abx080008-1mg 1 mg
EUR 1345.2

Morphine (BSA)

abx080032-1mg 1 mg
EUR 444

Morphine (BSA)

abx080033-1mg 1 mg
EUR 444

Morphine (BSA)

abx080034-1mg 1 mg
EUR 444

Ketamine (BSA)

abx080046-1mg 1 mg
EUR 543.6

Ketamine (BSA)

abx080047-1mg 1 mg
EUR 627.6

Barbital (BSA)

abx080049-1mg 1 mg
EUR 543.6

Morphine (BSA)

abx080051-1mg 1 mg
EUR 543.6

Cotinine (BSA)

abx080054-1mg 1 mg
EUR 577.2

BSA Antibody

1-CSB-PA000390
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against BSA. Recognizes BSA from Cow. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:2000-5000

BSA Antibody

1-CSB-PA272395
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against BSA. Recognizes BSA from Bovine. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:2000-1:10000, WB:1:1000-1:5000

BSA Antibody

1-CSB-PA592874
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against BSA. Recognizes BSA from Bovine. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:2000-1:10000, WB:1:1000-1:5000

Cortisol (BSA)

20-abx165679
  • EUR 678.00
  • EUR 309.60
  • EUR 1996.80
  • EUR 794.40
  • EUR 493.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Dopamine (BSA)

20-abx165709
  • EUR 844.80
  • EUR 343.20
  • EUR 2598.00
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Oxazepam [BSA]

DAG3106 1 mg
EUR 1076.4

Acrolein [BSA]

DAG3266 100ug
EUR 1248

Agmatine [BSA]

DAG3267 100ug
EUR 1014

Dopamine [BSA]

DAG3302 1mg
EUR 1326

Naproxen [BSA]

DAG3370 250ug
EUR 702

Rotenone [BSA]

DAG3400 mg
EUR 936

Fentanyl [BSA]

DAG398 1 mg
EUR 836.4

Degenerative IVD Conditioned Media and Acidic pH Sensitize Sensory Neurons to Cyclic Tensile Pressure.

Low again ache is amongst the main causes of incapacity worldwide. The degenerative intervertebral disc (IVD) surroundings accommodates pathologically excessive ranges of inflammatory cytokines and acidic pH hypothesized to contribute to again ache by sensitizing nociceptive neurons to stimuli that will not be painful in wholesome sufferers. We hypothesized that the degenerative IVD surroundings drives discogenic ache by sensitizing nociceptive neurons to mechanical loading. To check this speculation, we developed an in vitro mannequin that facilitated the investigation of interactions between the degenerative IVD surroundings, nociceptive neurons innervating the IVD and mechanical loading of the disc; and, the identification of the underlying mechanism of degenerative IVD induced nociceptive neuron sensitization.

In our mannequin, rat DRG neurons had been seeding onto bovine AF tissue, uncovered to degenerative IVD conditioned media and/or acidic pH, and subjected to cyclic tensile pressure (1 Hz; 1-6 % pressure) throughout measurement of DRG sensory neuron exercise by way of calcium imaging. Utilizing this mannequin, we demonstrated that each degenerative IVD conditioned media and degenerative IVD acidic pH ranges induced elevated nociceptive neuron activation in response to physiologic ranges of mechanical pressure.

As well as, IL-6 was demonstrated to mediate degenerative IVD conditioned media induced elevated nociceptive neuron activation. These outcomes reveal IL-6 mediates degenerative IVD induced neuron sensitization to mechanical loading and additional establishes IL-6 as a possible therapeutic goal for the therapy of discogenic ache. Information additional suggests the degenerative IVD surroundings accommodates a number of neuron sensitization pathways (IL-6, pH) which will contribute to discogenic ache. This text is protected by copyright. All rights reserved

Rising a spine – purposeful biomaterials and buildings for intervertebral disc (IVD) restore and regeneration: challenges, improvements, and future instructions.

Again ache and related maladies can account for an immense quantity of healthcare value and lack of productiveness within the office. Particularly, backbone associated accidents within the US have an effect on upwards of 5.7 million folks annually.

The degenerative disc illness therapy nearly at all times arises resulting from a scientific presentation of ache and/or discomfort. Most well-liked conservative therapy modalities embrace using non-steroidal anti-inflammatory drugs, bodily remedy, therapeutic massage, acupuncture, chiropractic work, and dietary dietary supplements like glucosamine and chondroitin.

Synthetic disc alternative, also called whole disc alternative, is a therapy various to spinal fusion. The purpose of synthetic disc prostheses is to duplicate the conventional biomechanics of the backbone phase, thereby stopping additional harm to neighboring sections.

Synthetic purposeful disc alternative by way of everlasting steel and polymer-based elements continues to evolve, however is way from recapitulating native disc construction and performance, and suffers from the chance of unsuccessful tissue integration and machine failure. Tissue engineering and regenerative medication methods mix novel materials buildings, bioactive elements and stem cells alone or together to restore and regenerate the IVD.

These efforts are at very early levels and a extra in-depth understanding of IVD metabolism and mobile surroundings may also result in a clearer understanding of the native surroundings which the tissue engineering scaffold ought to mimic. The present overview focusses on the methods for a profitable regenerative scaffold for IVD regeneration and the necessity for outlining new supplies, environments, and elements which might be so finely tuned within the wholesome human intervertebral disc in hopes of treating such a prevalent degenerative course of.

Speedy Detection of KPC-Producing Enterobacterales Inclined to Imipenem/Relebactam by Utilizing the MALDI-TOF MS MBT STAR-Carba IVD Assay 

KPC-producing Enterobacterales symbolize a severe public well being concern. Restricted therapeutic choices can be found for therapy, nevertheless, the novel mixture of imipenem/relebactam represents a promising various. To protect the exercise of this new antibiotic mixture, solely focused remedies will probably be advisable, and fast checks to detect prone micro organism are subsequently urgently wanted. Right here, we suggest a MALDI-TOF-based technique utilizing the MBT STAR-Carba IVD assay, Bruker Daltonik, to detect KPC-producing Enterobacterales prone to imipenem/relebactam in a random collection of 143 scientific isolates earlier molecular characterised, carrying 97 blaKPC, 1 blaGES, 12blaVIM, 4blaIMP, 3blaNDM, and 26blaOXA-48-like. Species identification was confirmed by MALDI-TOF MS.

The molecular characterization of the isolates was carried out by the Xpert Carba-R Assay and the outcomes had been used as gold customary. Apart from, all isolates had been submitted to imipenem and imipenem/relebactam microdilution susceptibility testing. The assay confirmed an general sensitivity and specificity to detect class A-producing Enterobacterales prone to imipenem/relebactam of 98% (96/98) and 93% (42/45), respectively. This MALDI-TOF-based methodology, with a turnaround time of lower than 1 h, is a dependable take a look at for detecting imipenem/relebactam exercise and its inclusion in routine laboratory screening would facilitate the proper use of this new mixture of antimicrobials as a focused therapy.

 

 

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